| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-무기재료 |
| 제목 |
Plasmonic Nanostructure based Light-enhanced Bioorthogonal Catalyst for Cancer Treatment |
| 초록 |
Bioorthogonal catalyst could provied a platform for the changing of substrates to activated specieces that mimics the enzymes in biological reactions. Palladium catalysts are highly efficient catalyst for bioorthogonal reaction of prodrugs and pro-fluorophores, however, the intrinsically insufficient catalytic activities have resticted their biological in vivo appication. Herein, we developed the palladium catalysts hybrid with plasmonic nanostructure to enhance the bioorthogonal catalytic activities by introducing the light. The light can modulate the catalytic performance of these bioorthogonal nanocatalysts in terms of LSPR induced hot carrier generation and local field enhancement, which in return, would enhance the bioorthogonal catalytic activities and generate more activated drugs at the given condition. In addition, photothermal effect will be incorporated to achieve synergistic photothermal and chemotherapy. |
| 저자 |
유수빈1, 장도협2, 김동하1, 김세훈2
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| 소속 |
1이화여자대, 2Korea Institute of Science and Technology |
| 키워드 |
Bioorthogonal chemistry; localized surface plasmon resonance; phototheral therapy; chemotherapy; prodrug
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| E-Mail |
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