| 초록 |
Bone defects which can occur in patients suffering from trauma, infection or tumor resection need intervention therapy to achieve sufficient restoration. However, traditional bone grafts cannot completely meet the clinical requirements. In recent years, 3D printing scaffolds have gained increasing interest as an alternative for bone reconstruction. However, their insufficient biological properties for bone regeneration still remained as a critical problem. In this study, we fabricated a growth factor-loaded PCL 3D printing scaffold with leaf-stacked structure which can allow sustained release of the growth factor as well as improved cell adhesiveness. The morphology, mechanical properties, growth factor release behavior and cell adhesiveness/proliferation/differentiation (in vitro) and new bone formation using beagle dog animal model (in vivo) of 3D printing scaffold with leaf-stacked structure were investigated. |
