| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
PEGylated human serum albumin nanocarrier for chemotherapy |
| 초록 |
Paclitaxel(PTX) is representative chemo-drug which has high effect and low solubility. PTX needs oil/detergent-based solvent to be dissolved due to its poor solubility in an aqueous environment. However, those formulations often cause undesirable complications including hypersensitivity reactions and limited tumor distribution, resulting in a lower dose than recommended dose. Now, we introduce a facile and oil free method to prepare albumin-based PTX nanoparticles for efficient systemic cancer therapy using a conjugate of human serum albumin (HSA) and poly(ethylene glycol) (PEG). PTX were efficiently incorporated in the self-assembled PEGyl-HSA nanoparticles (PEGyl-HSA/PTX) using a simple film casting and re-hydration procedure without additional processes such as application of high pressure/shear or chemical crosslinking. The spherical PEGyl-HSA nanoparticle mediates efficient cellular delivery, leading to high cytotoxicity in various breast cancer cells. |
| 저자 |
김동민, 정재백, 임수연, 김다훤, 조희주, 정지훈
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| 소속 |
성균관대 |
| 키워드 |
Drug dissolution; oil-free formulation; human serum albumin; self-assembled nanoparticle; systemic delivery |
| E-Mail |
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