| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Dendritic Gold Nanoplarticle Approach to the Efficient Delivery of siRNA in Cancer Therapy |
| 초록 |
RNA interference (RNAi) has received wide attention due to the therapeutic potential of siRNA. However, owing to its rigid double-stranded structure, it is difficult to form tight complex with conventional cationic carriers. Therefore, forming stabilized siRNA/carrier complexes is prerequisites for efficient siRNA delivery. In this study, we synthesized dendritic gold nanoparticles (Au@MCs) using polymeric micelles as a nano-scale template. The new platform of dendritic gold nanoparticles (Au@MC) could give a chance to solve the siRNA encapsulation problem by ionic interaction but also physical interaction, leading to serum stability and improved gene silencing effect. |
| 저자 |
김다훤, 임수연, LYUSIYAN, 황위보, 박채은, 김병덕, 정지훈
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| 소속 |
성균관대 |
| 키워드 |
gold nanoparticles; stabilizing polymeric micelles; gene silencing
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| E-Mail |
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