| 초록 |
Since burn wounds are complicated traumas accompanying oxidative stress and impairment of inherent cellular defense mechanisms against external bacteria, it is of great significance to develop new effective topical antipyrotics. Developing nanomaterials with excellent antioxidative and anti-inflammatory activities can be a potential strategy as an alternative to previous antimicrobials-based antipyrotics for effective burn injury treatment. Herein, we report a facile approach to produce thin WS2 nanosheets functionalized with PCL-b-PEG (2H-WS2), showing the sustainable scavenging ability for broad-spectrum reactive oxygen species and reactive nitrogen species. Especially, 2H-WS2 nanosheets with excellent biocompatibility exhibited the outstanding therapeutic efficacy in burn injury mouse models by reducing oxidative stress and inflammatory response along with promoting the secretion of antimicrobial peptides, leading to accelerating skin regeneration. |
