초록 |
Polymersomes have attracted particular interest as candidate materials for biomedical applications. Amphiphilic copolymers have higher molecular weights than phospholipids and can associate to form a more entangled membrane with improved mechanical properties. However, the development of biological applications of polymersomes has been limited by a lack of permeation pathways for hydrophilic solutes. Herein we report the preparation of polymersomes with pH-sensitive membranes using a biodegradable polymer designed by grafting together a copolymer using methoxy poly(ethylene glycol), poly(D,L-lactide) (PLA), and poly(β-amino ester) (PAE). After preparation by solvent exchange method, the pH-sensitive polymersomes exhibits pH-sensitive permeability against hydrophilic solutes at below pH 6.5. |