화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터)
권호 35권 1호
발표분야 의료용 고분자 부문위원회
제목 pH-Sensitive Polymersome with Tuning Permeable Membrane for Drug Delivery carrier
초록 Polymersomes have attracted particular interest as candidate materials for biomedical applications. Amphiphilic copolymers have higher molecular weights than phospholipids and can associate to form a more entangled membrane with improved mechanical properties. However, the development of biological applications of polymersomes has been limited by a lack of permeation pathways for hydrophilic solutes. Herein we report the preparation of polymersomes with pH-sensitive membranes using a biodegradable polymer designed by grafting together a copolymer using methoxy poly(ethylene glycol), poly(D,L-lactide) (PLA), and poly(β-amino ester) (PAE). After preparation by solvent exchange method, the pH-sensitive polymersomes exhibits pH-sensitive permeability against hydrophilic solutes at below pH 6.5.
저자 김민상, 이두성
소속 성균관대
키워드 copolymer; polymersome; pH-sensitive
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