| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
ROS-Sensitive Degradable PEG-PCL-PEG Triblock Copolymer Thermogel |
| 초록 |
Design of reactive oxygen species (ROS)-sensitive degradable polymer can be a promising strategy for biomedical polymers with a slow degradation kinetics. Here we are reporting a thermogelling poly(ethylene glycol)-polycaprolactone-poly(ethylene glycol) (PEG-PCL-PEG) triblock copolymer prepared through connecting poly(ethylene glycol)-polycaprolactone diblock copolymers using oxalyl chloride. The PEG-PCL-PEG triblock copolymer formed themogellation as the temperature increased. The in vitro degradation of the PEG-PCL-PEG gel was sensitive to hydrogen peroxide and PEG-PCL were formed in the presence of hydrogen peroxide (1.0 mM). In vivo study was performed by injection aqueous polymer solution (36.0 wt.%, 0.5 mL) into the subcutaneous layer of rats. The H&E staining around the gel depot exhibited increase of immune cells initially, however the gel is completely disappeared in 21 days. The in situ formed gel provided a sustained release profile of the cyclosporine over 21 days. |
| 저자 |
이현정, ZHENGYU PIAO, 손승이, 정병문
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| 소속 |
이화여자대 |
| 키워드 |
ROS-Sensitive; Degradable; Thermogel
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| E-Mail |
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