| 학회 |
한국고분자학회 |
| 학술대회 |
2022년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
47권 1호 |
| 발표분야 |
대학원생 구두발표(토론II): 감염병 대응을 위한 생체 물질 전달용 고분자 연구 |
| 제목 |
Combination of Electrical Ablation and Functional Nanoparticle for In Situ Cancer Vaccination |
| 초록 |
Cancer immunotherapy is a cutting-edge treatment that employs immune system components to combat cancer. Electrical ablation (EA) is a newly developed tumor treatment approach that uses pulsed electronic fields to trigger apoptotic cell death in cancer cells without utilizing thermal energy. The EA can cause cancer associated antigens and damage-associated molecular patterns (DAMPs) to be produced, which can trigger anti-cancer immune responses. We established a new in situ cancer vaccination technique for better cancer treatment efficacy using a combination of EA and functional nanoparticle coupled with immune adjuvant in this work. The synergistic effect of EA with functional nanoparticle dramatically increases anti-cancer immune responses, according to in vitro and in vivo tests. Overall, we believe that the unique in situ vaccination of EA with functional nanoparticle offers a lot of promise for treating numerous incurable cancers. |
| 저자 |
한준혁, 박우람
|
| 소속 |
성균관대 |
| 키워드 |
cancer vaccine; nanoparticle; electrical ablation; immunotherapy; image-guided therapy
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| E-Mail |
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