| 학회 |
한국고분자학회 |
| 학술대회 |
2022년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
47권 1호 |
| 발표분야 |
대학원생 구두발표(영어발표, 발표15분) |
| 제목 |
MOF nanoparticles with ice surface-microcurvature control for efficient cell-cryopreservation |
| 초록 |
Ice binding proteins (IBPs) have been recognized as cryoprotectants (CPAs) for the survival of organisms in sub-zero conditions because of lowering the freezing point of water and ice recrystallization inhibition (IRI) by binding to the growing ice surface. CPAs developed by mimicking these properties use the interaction with ice to prevent the cryoinjury of cells or tissues. Herein, zirconium (Zr)-based MOF-801 nanoparticles (NPs) with high biocompatibility were used as CPAs in an aqueous solution. The smallest NP induces a high micro-curvature of the ice surface, showing a higher IRI effect. Surface-functionalization of MOF-801 NPs with ice-binding pendants confer hydrophilic/hydrophobic duality to the NPs, resulting in hydrogen bonding with ice and preventing water molecules from assimilating with the ice surface, leading to superior cell CPAs efficiency. This study suggests low-cost, high-dose MOF NPs CPA for organ/cord blood preservation, and vaccine/pharmaceutical applications. |
| 저자 |
전나영1, 이지연1, 정인호2, 박현우3, 이희정3, 이창환2, 이은지1
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| 소속 |
1광주과학기술원, 2서울아산병원, 3한국재료(연) |
| 키워드 |
metal-organic framework (MOF) nanoparticles; microcurvature control; ice-binding motifs; ice recrystallization inhibitors; cryoprotectants
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| E-Mail |
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