| 초록 |
A novel method for the preparation of PLGA (poly(lactide-co-glycolide) nanospheres has been designed and characterized based on the temperature-induced phase transition in the liquidized mixture of PLGA and Pluronic (Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock coplymer). PLGA with molecular weight of 100,000 or less exhibits the glass transition between 50 and 90 ℃ depending on the molecular weight and changes into liquid state above its glass transition temperature. Pluronic also exhibits the melting transition in the similar temperature range depending on PEO/PPO ratio. Based on these characteristics, the formation of microstructures of F-127/PLGA mixtures were induced for the preparation of PLGA nanospheres by the temperature-induced phase transition. We have identified that the microstructure of F-127/PLGA mixture can lead to the formation of PLGA nanospheres. For the application as a drug delivery vehicle, paclitaxel used as a potent anticancer drug was loaded into the PLGA nanospheres and the loading amount, the encapsulation efficiency and the release pattern from the nanospheres were measured. |
