| 학회 |
한국고분자학회 |
| 학술대회 |
2003년 가을 (10/10 ~ 10/11, 부경대학교) |
| 권호 |
28권 2호, p.8 |
| 발표분야 |
특별 심포지엄 |
| 제목 |
New Biomaterials Based on Native Silkworm Silk |
| 초록 |
Interest in the use of reprocessed silks such as fibroin in biotechnological materials and in biomedical applications derives from the unique mechanical properties of these fibers and their biocompatibility and biodegradability. Furthermore, systematic in vivo studies indicate silk induces a foreign body response comparable to most commonly used degradable synthetic and natural polymers such as poly(glycolic acid)-poly(lactic acid) (PGA-PLA) copolymers and collagen. In the present study, we introduce new strategies to prepare biomaterials based on reprocessed native silkworm silk, such as for 2-D or 3-D scaffolds, wound dressings, elastic films, hydrogels, microspheres, nanosize fibers, and nanocomposites. The techniques to achieve these types of materials include electrospinning, blending or casting, biomineralization and the key aspect of the processing approach is based on generating concentrated (5.6-30%) aqueous solutions of fibroin through a modified silk solubilization procedure. Furthermore, to enhance the potential biocompatibility of this material we have used only aqueous processing and avoided the use of organic solvents or heavy metal catalysts that can pose problems when the processed materials are exposed to cells in vitro or in vivo. Thus, we developed an all-aqueous process for manufacturing new silk protein-based biomaterials at ambient conditions. |
| 저자 |
진형준1, Jaehyung Park2, Ung-jin Kim3, Jinsong Chen4, Chunmei Li5, Rina Nazarov6, Vassilis Karageorgiou7, Regina Valluzzi2, David L. Kaplan3
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| 소속 |
1인하대, 2Department of Chemical and Biological Engineering, 3Tufts Univ., 44 Colby Street, 5Medford, 6MA 02155, 7USA |
| 키워드 |
silk; biomaterials; fibroin; scaffolds; tissue engineering; drug delivery
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| E-Mail |
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