| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Synthesis and Characterization of Chitosan-b-PCL Copolymer for Drug Delivery |
| 초록 |
In this study, we synthesized ampiphilic copolymer consist of chitosan and PCL for anticancer drug delivery. The chitosan-b-PCL block copolymer was synthesized by radical polymerization. Firstly, chitosan as a hydrophilic moiety was dissolved in distilled water. Then, initiator agent was added in chitosan solution and reacted for 1hr at 60℃. Continuously, synthesized PCL-macromer with PCL and acryloyl chloride was slowly added in the reactant and stirred for 6hr at 60℃. The reactant was precipitated by acetone and harvested vacuum dry. The characterization of chitosan-b-PCL block copolymer was analyzed by 1H NMR, FT-IR, DLS and TEM. These results suggest that ampiphilic copolymer was able to apply as drug carrier. This work was supported by National Research Foundation of Korea (NRF) grant funded by the Ministry of Science, ICT & Future Planning. (No. NRF-2014R1A2A1A10053027). |
| 저자 |
나재운, 김명렬, 최창용, 박소영, 홍웅길, 이현수, 최선주, 김태훈, 정경원
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| 소속 |
순천대 |
| 키워드 |
chitosan; PCL; chitosan-b-PCL copolymer; characterization
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| E-Mail |
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