| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
의료용고분자 부문위원회 |
| 제목 |
Fabrication of Hybrid PAH/DP Nanocapsules Containing Magnetite Nanoparticles for Combined Diagnosis and Photodynamic Cancer Therapy |
| 초록 |
Photodynamic therapy (PDT) is a promising method for the treatment of several diseases including cancer. It involves the systemic administration of photosensitizers such as porphyrin. In this work, a 3rd generation dendrimerporphyrin (DP) with 32 carboxyl groups on the periphery was used as a component to prepare a layer-by-layer structure. To enhance the efficacy and tumor-specificity of PDT, poly(allylamine hydro chloride) / DP nanocarrier was constructed through a LbL self-assembly of PAH and DP on a removable template. Moreover, multifunctional nanocarrier was fabricated which is capable to diagnose cancer cells using MR contrast agent by embedding superpara magnetite nanoparticle on nanocarrier with PDT effect. Finally, the agent for surface modification could be coated onto the nanocarriers through electrostatic interaction between DP and PEG. Thus, diagnosis and treatment of cancer cells were implemented after injecting the nanocarrier into the cancer cells. |
| 저자 |
임태극, 윤희재, 이혜원, 정의석, 장우동, 고원건
|
| 소속 |
연세대 |
| 키워드 |
Layer-by-layer; Drug delivery; Colloids; Polymer capsules; Polyelectrolytes |
| E-Mail |
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