| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Synergistic inhibitory effect of concave hemisphere pattern and layer by layer deposition on capsular contracture of silicone implants |
| 초록 |
As breast augmentation is the largest part of plastic surgery in the world, the study of capsular contracture which is the most frequent side effect of silicone implants becomes important. Capsular contracture is caused by excessive fibrosis to the periphery of the implant. Surface roughness has been studied for controlling cellular behavior. In this study, concave hemisphere pattern of different sizes ranging from 38 μm to 100 μm was fabricated on PDMS surface to find out ideal roughness to reduce capsular contracture. Microparticles fabricated by SPG membrane technique were used to fabricate patterns of uniform size. Chemical coating was also conducted as chemical cue. Layer by layer deposition was used using natural polymer, poly-L-lyine and hyaluronic acid, as materials. Synergistic inhibitory effect of concave hemisphere pattern and LbL deposition was analyzed in vitro and in vivo and 100 μm hemisphere pattern with LbL deposition was the most effective. |
| 저자 |
유병용1, 국윤민1, 민지홍1, 정윤아1, 김병휘2, 허찬영2, 고원건1
|
| 소속 |
1연세대, 2서울대 |
| 키워드 |
Biomaterials; Surface modification; PDMS; Silicone implant; Capsular contracture; Fibrosis
|
| E-Mail |
|
