| 학회 |
한국공업화학회 |
| 학술대회 |
2011년 가을 (11/02 ~ 11/04, 경원대학교) |
| 권호 |
15권 2호 |
| 발표분야 |
고분자 |
| 제목 |
In vitro drug release behaviors and permeation properties of glycosaminoglycan hydrogels system prepared by radiation technique |
| 초록 |
Natural polysaccharides such as hyaluronic acid (HA) and chondroitin sulfate (CS) have been extensively studied in medical applications since they can provide intrinsic biological activity when used as the basis for biomatierls. Glycosaminoglycans, including HA and CS, are aminosugar-containing polysaccharides in the extracellular matrix of all vertebrates. To design the artificial skin modelfor alternative tests to animal experiments, we synthesized hyaluronic acid and chodroitin sulfate derivatives with polymerizable residues with precise control over the substitution degree. The hyaluronic acid/chodroitin sulfate-based hydrogels were prepared by using a radiation technique. The enzymatic degradation kinetics, the drug release behaviors and drug permeation properties of the hydrogels were investigated to evaluate the feasibility for artificial skin substitutes. |
| 저자 |
신미래1, 자오린린1, 권희정2, 임윤묵2, 노영창2, 김소연1
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| 소속 |
1충남대, 2한국원자력(연) |
| 키워드 |
hydrogel; tissue engineering; skin substitutes
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| E-Mail |
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