| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Hypoxia-sensitive block copolymer bearing nitroaromatics for drug delivery |
| 초록 |
Hypoxia, an oxygen-deficient condition, is one of the representative hallmarks of cancer. In this study, we prepared an amphiphilic block copolymer which can form self-assembled nanoparticles in biological fluids and selectively release the hydrophobic agents under hypoxic conditions. The copolymer was prepared using poly(ethylene glycol) as the hydrophilic block and poly(ε-(4-nitro)benzyloxycarbonyl-L-lysine) as the hydrophobic block. The block copolymer bearing nitroaromatics formed nanoparticles and encapsulated doxorubicin (DOX) in an aqueous condition. The DOX-loaded micelles showed rapid intracellular release of DOX under the hypoxic condition. Overall, we have demonstrated that hypoxia-sensitive block copolymer has the high potential as a drug carrier for treatment of hypoxia-associated diseases. |
| 저자 |
Thavasyappan thambi, 손소영, 이두성, 박재형
|
| 소속 |
성균관대 |
| 키워드 |
hypoxia; doxorubicin; drug delivery; block copolymer
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| E-Mail |
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