| 학회 |
한국공업화학회 |
| 학술대회 |
2013년 봄 (05/01 ~ 05/03, ICC JEJU) |
| 권호 |
17권 1호 |
| 발표분야 |
포스터-정밀화학 |
| 제목 |
Folate-grafted OCMCh-Poly-L-lysine Gene Carrier for targeted Gene Delivery in vitro |
| 초록 |
Among non-viral gene delivery vector, Chitosan has been considered to be good material because it is known as a , biodegradable, biocompatible and low toxicity . Poly-L-Lysine (PLL), Cationic polymer was widely used in gene delivery system due to its potential that the structure facilitates various modifications with hydrophilic, hydrophobic and amphiphilic polymers. The folate receptor (FR) is an useful biological target for the management of many human cancers. FA-PEG-OCMCh-PLL particles were characterized by FT-IR, 1H-NMR and DLS analysis. In addition, transfection efficiency proposed that it is effective on gene delivery system. This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education, Science and Technology(2011-0012039) |
| 저자 |
박순정, 변지예, 박영훈, 최창용, 박성철, 나재운, 장미경
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| 소속 |
순천대 |
| 키워드 |
gene carrier; GDS; PLL; FA; chitosan; target moiety
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| E-Mail |
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