| 학회 |
한국공업화학회 |
| 학술대회 |
2013년 봄 (05/01 ~ 05/03, ICC JEJU) |
| 권호 |
17권 1호 |
| 발표분야 |
포스터-정밀화학 |
| 제목 |
Targeted delivery of Doxorubicin-Utilizing O-carboxymethyl Chitosan Nanoparticles with PEGylated Folate |
| 초록 |
Doxorubicin (DOX) conjugated O-carboxymethyl chitosan (OCMCh) nanoparticle was synthesized by dimethylmaleate bond between DOX and OCMCh (OCM-MD). Folate (FA) was conjugated to OCM-MD conjugate nanoparticles via PEGylation of PEG terminal group linking of the resulted amines to OCMCh-C6 position (FA-PEG-OCM-MD). Conjugation was confirmed by Fourier transform infrared spectroscopy (FT-IR), and 1H nuclear magnetic resonance spectroscopy (1H NMR) studies. Dynamic light scattering (DLS) was used to characterize the nanoparticles. In-vitro antitumor test of OCM-MD and FA-PEG-OCM-MD nanoparticles against HeLa cell. These results suggest that FA-PEG-OCM-MD can be applied to design cancer therapeutics. |
| 저자 |
김태훈, 박준규, 손동희, 김원석, 최창용, 박성철, 박영훈, 장미경, 나재운
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| 소속 |
순천대 |
| 키워드 |
O-carboxymethyl chitosan; Doxorubicin; dimethyl maleate bond; Folate
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| E-Mail |
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