| 학회 |
한국공업화학회 |
| 학술대회 |
2013년 봄 (05/01 ~ 05/03, ICC JEJU) |
| 권호 |
17권 1호 |
| 발표분야 |
포스터-정밀화학 |
| 제목 |
Self-assembled nanoparticles based on hydrophobically modfied O-carboxymethyl chitosan as carriers for antibiotics |
| 초록 |
The objective of the present study was to develop a new drug carrier consisting of O-Carboxylmethyl chitosan (OCMCh) with fatty acid (Fa). The particles form the self-aggregates in an aqueous phase by hydrophobic interaction between hydrophobic Fa attached to OCMCh and ciprofloxacin (OCM-Fa-Cip). We found that OCM-Fa made to be soluble the ciprofloxacin, which has poor solubility in water. Characterization was confirmed by FT-IR, 1H-NMR, DLS and TEM studies. In-vitro antimicrobial test of OCM-Fa-Cip nanoparticles was investgated against various strain. These results suggest that OCM-FA-Cip can be applied as a carrier of antibiotics. Acknowledgement : This research was financially supported by the Ministry of Knowledge Economy(MKE), Korea Institute for Advancement of Technology(KIAT) and Honam Leading Industry office through the Leading Industry Development for Economic Region. |
| 저자 |
정경원1, 김영민1, 남정표1, 최창용2, 박성철1, 장미경1, 나재운1
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| 소속 |
1순천대, 2다이나믹 |
| 키워드 |
ntibiotics; O-Carboxylmethyl chitosan; fatty acid; ciprofloxacin
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| E-Mail |
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