| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
pH-Responsibility of Polyethyleneimides(PEIs) Coated Mesoporous Silica and its Application for Drug Delivery System |
| 초록 |
Controlled drug delivery system (DDS) based on nanoparticles has received a lot of attention due to their high drug loading capacity and biocompatibility. The mesoporous silica nanoparticles(MSNs) have been researched for the biological applications with extensive specific surface, large pore volume, tunable particle and pore size. As changing a gate keeper material, it can encapsulate various drugs and control each drug’s release. In this work, we have coated MSNs with cancer cell targeting group modified Polyethyleneimides(PEIs) through electrostatic interaction and investigated drug release ability by changing electrostatic interaction in the low pH condition. Transmission Electron Microscopy (TEM) and Scanning Electron Microscopy (SEM) show morphology of mesoporous nanoparticles. We can confirm the structure of polymers by nuclear magnetic resonance (NMR) and FT-IR spectroscopy. Time-resolved fluorescence spectroscopy analysis shows drug release profile under pH change. |
| 저자 |
박지혜, 성아름, 박성수, 하창식
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| 소속 |
부산대 |
| 키워드 |
mesoporus silica nanoparticles; biodegradable polymer; PEIs; pH-responsive drug delivery system
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| E-Mail |
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