| 초록 |
Hyaluronic acid hydrogels are widely used in medical applications for its biocompatibility and versatility. Nevertheless, common HA hydrogels have limitations in terms of property control as well as cell attachment. In this study, a hybrid hydrogel was formed with hyaluronic acid-methacrylate (HAMA) and silk fibroin-methacrylate (SFMA) via photo-crosslinking and physical cross-links of SF chains. The photo-crosslinking was conducted by irradiating UV light in the presence of photoinitiator and subsequently treated with ethanol for further physical cross-linking. With an increasing SFMA content, hydrogel stiffness increased, while the photo-gelation was delayed. In addition, both cell adhesion and proliferation was improved in the presence of SFMA because silk protein provided cell adhesion ligands. |
