| 초록 |
Photoluminescent quantum sized carbon dot (Cdot) is a potential bio-imaging agent with superior chemical inertness and less toxicity compared to quantum dots. In this work, bio-imaging of hyaluronic acid (HA) derivatives was carried out using luminescent Cdots. The Cdots were prepared by carbonizing carbon precursors in a hot solvent, and the surface of Cdots was modified with polyethylene glycol diamine to introduce amine functional groups. HA-Cdot conjugate was synthesized via amide bond formation with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC). The HA-Cdot conjugate was characterized by UV-visible spectrophotometer, photoluminescent spectroscopy, optical fluorescent microscopy, and transmission electron microscopy (TEM). Furthermore, the HA-Cdot conjugate was successfully applied to bio-imaging for targeted delivery of HA derivatives reflecting the possibility of HA derivatives as novel drug delivery carriers and Cdot as a promising bio-imaging agent. |
