| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
Korea-Taiwan Joint Symposium: Emerging Technology in Polymer Science and Engineering (English) |
| 제목 |
Delivery the Chemotherapeutic Drug through Redox Sensitive Polymeric Nano-carrier for Cancer Treatment |
| 초록 |
Smart drug delivery systems have showed great potential for the disease treatment that can be stimulated by the changes in the environmental parameter. Among all the smart carrier, biocompatible amphiphilic block copolymers have been considered as the most promising bio-materials to delivery of anticancer drug due to the formation core-shell nanoparticles protect the above agents. The self-assembled nanostructure exhibited several advantage when delivery the therapeutic drug, such as improve the solubility and stability of drug before transportation to targeting organs. However, the non-select drug release from the amphiphilic copolymer limit their application in the treatment of cancer disease. Thus, the introducing of stimuli sensitive and easily cleavable groups in the polymer chain during the synthesis of materials is essential to achieve rapid and relatively completely drug release from the carrier in the cancer environment. Therefore, we have synthesized two kind of Di-selenide contained copolymer system (Bi(mPEG-SeSe)-b-(PCL) and Bi(mPEG-b-PLGA)-Se2) and evaluation their drug released mechanism of above two approach. Di-selenide containing block copolymer exhibited the selective drug release only in cancer cells, which can be utilized as targeting strategy for delivery anticancer drug. |
| 저자 |
Hsieh-Chih Tsai |
| 소속 |
National Taiwan Univ. of Science and Technology |
| 키워드 |
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| E-Mail |
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