| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Cancer Specific Fluorescence Imaging Using Folate-Alginate Nanoparticles |
| 초록 |
In cancer nanomedicine, numerous studies have been conducted on the surface modification and transport capacity of nanoparticles (NPs); however, biological barriers, such as enzymatic degradation or non-specific delivery during circulation, remain to be cleared. Herein, we developed pH-sensitive NPs that degrade in an acidic environment and release 5-aminolevulinic acid (5ALA) to the target site. NPs were prepared by conjugating alginate with folic acid, followed by encapsulation of 5ALA through a water-in-oil (W/O) emulsion method. AF NPs were specifically internalized by cancer cells through receptor-mediated endocytosis. After alginate was deprotonated in the lysosomes and released 5ALA, which was converted to protoporphyrin IX (PpIX) through mitochondrial heme synthesis. Our study outcomes demonstrated that AF NPs were not degraded, and fluorescent precursors were specifically and accurately delivered to cancer cells to generate fluorescence. |
| 저자 |
이사라, 배채원, 김창헌, 박예철, 정한나, 이강원
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| 소속 |
서울대 |
| 키워드 |
alginate; folic acid; 5-aminolevulinic acid; nanoparticle; nanomedicine; bioimaging; cancer diagnosis
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| E-Mail |
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