| 학회 |
한국화학공학회 |
| 학술대회 |
2019년 봄 (04/24 ~ 04/26, 제주국제컨벤션센터) |
| 권호 |
25권 1호, p.368 |
| 발표분야 |
생물화공(Biochemical Engineering) |
| 제목 |
Liquid Metal Nanotransformer for Cancer Treatment |
| 초록 |
Among various drug delivery systems, nanocarriers consist of liquid metal are being actively studied. Eutectic Gallium-Indium alloy (EGaIn) liquid metal has been reported to have a low melting point, low toxicity and good tissue/cell penetration. EGaIn has a characteristic property, deforming by the control of light and/or heat irradiations. In this study, we describe transformable liquid metal nanoparticles delivering anti-tumor drug molecules. These “nanotransformer” particles are synthesized through a sonication and an extrusion of either EGaIn solution or EGaIn mixed with amphiphilic lipids. The resulting nanotransformers are loaded with anti-tumor drung, doxorubicin, that can be released upon deformation of EGaIn nanoparticles excited with light. The nanotransformer particles showed no toxicity in mammalian cells. A proper photo-thermal ligand added to the nanotransformer helped increasing the yield of deformed liquid metal nanoparticles, resulting in efficient drug delivery. |
| 저자 |
김다솜, 황장선, 최용현, 권예진, 장재희, 이경우, 최종훈
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| 소속 |
중앙대 |
| 키워드 |
생물화학공학 |
| E-Mail |
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| 원문파일 |
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