| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Osteogenesis Differentiation of Rabbit Bone Marrow Mesenchymal Stem Cells in Bone-like Microenvironmental |
| 초록 |
In this study, bone-like microenvironmental structures which can be able to differentiate from BMSCs to osteogenic cells were fabricated for bone repair. And the effect of hydroxyapatite (HAp) as soluble factor was confirmed by adding various contents onto silk fibroin structure. Cell proliferation activity was measured via MTT assay, differentiation behavior was confirmed ALP activity assay and biological assay for osteocalcin, collagen I and RUNX2 was performed. As a result, various methods of analysis showed that the osteogenic differentiation value of 10% HAp onto silk fibroin was better than other groups. This study suggests that using bone-like microenvironmental structures with HAp become positive effect on osteogenesis of BMSC and osseous growth. This research was supported by NRF-2012M3A9C6050204, Bio-industry Technology Development Program (KMFAFF, 112007-05-2-SB010) and the Brain Korea 21 PLUS Project, NRF. |
| 저자 |
박진영1, 김수민1, 국현1, 김혜민1, 오승창1, 김은영1, 송정은1, 박찬흠2, 강길선1
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| 소속 |
1전북대, 2한림대 |
| 키워드 |
Bone Marrow Mesenchymal Stem Cell(BMSC); Osteogenesis Differentiation; Bone Regeneration; Silk Fibroin; Hydroxyaparite(HAp)
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| E-Mail |
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