| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
대학원생 구두발표(영어발표, 발표15분) |
| 제목 |
Stimuli-responsive multistage nanoparticles for deep tumor penetration of doxorubicin |
| 초록 |
Heterogeneous drug distribution within tumor tissue is one of the major hurdles in improving overall therapeutic efficacy. To resolve this issue, we have developed stimuli-responsive multistage nanoparticles, named as transformable nanoparticles (TNPs), composed of pH-sensitive amphiphilic block copolymer, doxorubicin (DOX), and DOX-conjugated ultrasmall gold nanoparticles (DOX-NS). After systemic administration of DOX-loaded TNPs (DOX-TNPs), they were accumulated into the tumor interstitium followed by disassembly of polymeric nanoparticles responding to the mildly acidic tumor environment which triggers the release of DOX and DOX-NS. The released DOX was accumulated in the perivascular region and the DOX-NS could penetrate deeply into the inside of the tumor. After internalization of DOX-NS, DOX would be released by the cleavage of the ester bond. In this study, we successfully demonstrated a great potential of the multistage system of DOX-TNPs in anticancer drug delivery. |
| 저자 |
손소영, 디파간, 신솔, 고혜원, 전주은, 박재형
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| 소속 |
성균관대 |
| 키워드 |
multistage; deep penetration; doxorubicin
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| E-Mail |
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