화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터)
권호 43권 1호
발표분야 의료용 고분자 부문위원회 I
제목 Melanin-poly (ethylene glycol) (PEG) conjugate as a photothermal therapeutic agent
초록 Melanin absorbs light in various wavelength regions, but not dissolving in biological fluids. In this study, melanin was conjugated with polyethylene glycol (PEG) to increase availability for biomedical applications. Melanin-PEG conjugate (Mel-PEG) was self assembled in water and the mean diameter of nanoparticles was 237.8 nm. The nanoparticles did not show any precipitation in water. 1H NMR results confirmed that the PEG peaks were newly formed. Mel-PEG solution was injected into the thigh muscle of a mouse and exposed to 808 nm NIR laser with a power density of 1.5 W/cm2. Due to the intrinsic photothermal properties of melanin, the temperature of injection site was elevated to 65.4℃ after laser irradiation within 3 min. These results suggest that Mel-PEG nanoparticles has great potential as a phothothermal agent for photothermal cancer therapy.
저자 김민아, 이창문
소속 전남대
키워드 Melanin; Poly (ethylene glycol); Near infrared; Nanoparticle; Photothermal agent
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