| 학회 |
한국화학공학회 |
| 학술대회 |
2018년 가을 (10/24 ~ 10/26, 대구 EXCO) |
| 권호 |
24권 2호, p.2234 |
| 발표분야 |
WISET 여대학(원)생 공학연구팀제 지원사업 결과 발표대회(여성위원회) |
| 제목 |
Fabrication of Electrochemical miRNA-155 Biosensor Composed of with Multifunctional DNA Structure/Gold nanoparticle Heterolayer for Early Diagnosis of Breast Cancer |
| 초록 |
The importance of early diagnosis has been grown up to the breast cancer patients increased. In this study, authors fabricated the electrochemical biosensor composed of multifunctional DNA 3 way-junction (3WJ) and gold nanoparticles for detecting miRNA-155. The multifuctional DNA 3WJ was prepared for detecting miRNA-155, signal generation and immobilization process all at once. Gold nanoparticles were used for electrochemical signal amplification. After the gold nanoparticles were immobilized on the Au substrate, the probe is immobilized through the self-assembly. The surface of the Au substrate was investigated by atomic force microscopy (AFM). The miRNA-155 was detected using cyclic voltammetry (CV). The proposed biosensor can be a great platform for early detection of breast cancer in the future. Acknowledgements: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2018R1D1A1B07049407) and by Nano•Material Technology Development Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Science, ICT and Future Planning. (2009-0082580) |
| 저자 |
박순용1, 김수민1, 김윤경1, 정지우2, 김서현2, 한가음3, 박신영3, 이 택1
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| 소속 |
1광운대, 2용화여자고등학교, 3한양대 |
| 키워드 |
microRNA; miRNA-155; DNA 3 way-junction; Electrochmical biosensor; Cyclic voltammetry
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| E-Mail |
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| VOD |
VOD 보기 |
| 원문파일 |
초록 보기 |
