| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Inhibition of metastatic caner via nano-micelle generating degradable microneedles containing doxorubicin |
| 초록 |
Microneedle (MN) has been desired as a therapeutic tool which allow transcutaneous administration of diverse drugs with easily and painlessly. Herein, nano-micelle generating degradable MN was designed by a biocompatible amphiphilic tri-block copolymer. When formulate with doxorubicin (DOX) in the MN, the hydrophobic anticancer drug can be dissolved in an aqueous medium by entrapped in nano-micelles generated by dissolution of the MN. The transdermal application of the DOX-encapsulated MN can significantly inhibit the growth of melanoma in a mouse skin cancer model. Furthermore, owing to its small size (＜ 50 nm), the nano-micelle can efficiently migrate to the sentinel lymph nodes, killing the metastatic skin cancer cells. Therefore, the use of locally application of MN can be considered as a promising therapeutic device for the inhibition of metastatic melanoma. |
| 저자 |
임수연, 김다훤, 황위보, LYUSIYAN, 김병덕, 박채은, 정지훈
|
| 소속 |
성균관대 |
| 키워드 |
microneedle; doxorubicin; metastasis cancer; melanoma
|
| E-Mail |
|
