| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 |
19권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Ppa-iRGD-Q as a Depot Peptide for Effective Photodynamic Therapy |
| 초록 |
One of the major issues in photodynamic therapy (PDT) is the controlled release of singlet oxygen (1O2) for effective treatment with minimal side effects. Herein, we describe a pyropheophorbide a (Ppa) conjugated cyclic iRGD peptide with a quencher at the other end (Ppa-iRGD-Q). Ppa-iRGD-Q peptide was designed to recognize cancer cells by the RGD motif, and the Ppa could be internalized into cancer cells via protease cleavage. Subcutaneous injection of Ppa-iRGD-Q resulted in the formation of a protease operated depot, which remained stable at the peritumoral environment allowing sustained release of the Ppa. Ppa was well preserved within the tumor allowing in vivo detection of the fluorescence signal of Ppa and also effective generation of singlet oxygen. We propose Ppa-iRGD-Q as a suitable PDT drug candidate for the controlled release of the photosensitizer into the tumor. |
| 저자 |
박성준1, 조홍준2, 김영선3, 김세훈3, 이윤식1
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| 소속 |
1서울대, 2National Institutes of Health, 3한국과학기술(연) |
| 키워드 |
Photodynamic therapy; pheophorbide a; iRGD peptide; quencher; singlet oxygen
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| E-Mail |
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