| 초록 |
This paper demonstrates a reliable and simple method to fabricate a micropattern of nanoparticles using a soluble polymer template. The soluble polymer is terpolymer based on hydrophobic and hydrophilic structures, which is insoluble in aqueous solution but soluble in the mixture of ethanol and water. Due to its amphiphilicity, it easily sticks diverse surfaces including glass, silicon, gold and polymers. We micropatterned ~10 nm size of Au nanoparticles (Au-NPs), which were conjugated with RGD peptide, to confirm the feasibility as a generic methodology for the micropatterning of nanoparticles. It was carried out by a simple strategy: 1) microcontact printing of soluble polymer 2) incubating with a solution of Au-NPs 3) liftoff of template in the mixture of ethanol and deionized water. 50 µm size of features were successfully fabricated without any significant defects and nonspecific adsorption on the background. Micropatterns of bioactive nanoparticles were used for the patterning of cells with high spatial resolution. |
