| 초록 |
Magnetic particles have become very promising materials for drug delivery. However, preparation of magnetite particles with high surface area, biocompatibility, strong magnetic response and suitable particle size still remains a major challenge. In this report, magnetite nanocrystal clusters with high surface area were fabricated via a solvothermal process by introducing ammonium acetate as a porogen and trisodium citrate as a surface modification agent. Ibuprofen, as a model drug, was entrapped into the magnetite carriers. Low cytotoxicity in MCF-7 cell and in vitro constant drug release behavior combined with the high drug-loading efficiency and high saturation magnetization value demonstrated the potential of the as-synthesized magnetite materials in targeted drug release system. |
