| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
고분자 합성 |
| 제목 |
Histodenz Hyperbranched Polyglycerols:A New Type of X-ray Computed Tomography Contrast Agent |
| 초록 |
Using Histodenz as initiator, a novel type of hyperbranched polyglycerols (HBP) with controlled molecular weight have been synthesized via ring-opening multibranching polymerization. Preliminary evaluations were conducted for physicochemical characterization and in vivo computed tomography (CT) contrast enhancement in a rat model. This study showed the synthetic feasibility and potential utility for CT contrast enhancement achieved with a new type of hyperbranched polyglycerols. Further development of this class of macromolecular contrast agents will be required to define the optimal formulation, pharmacology, and the full range of diagnostic applications including tumor microvascular quantitative characterization by CT imaging |
| 저자 |
왕징1, 이해청2, 장리동1, 김일2
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| 소속 |
1부산대, 2합성고분자 생물접합 하이브리드 재료사업단 |
| 키워드 |
CT; Histodenz; Hyperbranched Polyglcerols (HBP); MRI; ring-opening polymerization
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| E-Mail |
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