| 학회 | 한국화학공학회 |
| 학술대회 | 2010년 봄 (04/22 ~ 04/23, 대구 EXCO) |
| 권호 | 16권 1호, p.367 |
| 발표분야 | 생물화공 |
| 제목 | Enantioselective conversion of methyl-2-chlorobenzoylformate using Saccharomyces cerevisiae as whole cell biocatalyst |
| 초록 | Clopidogrel is a platelet aggregation inhibitor widely administered to atherosclerotic patients with the risk of a heart attack or stroke that are caused by the formation of a clot in the blood. Plavix (clopidogrel bisulfate) is marketed worldwide in nearly 110 countries, with sales of $6.4 billion per year. It had been the second top selling drug in the world for a few years and was still growing by over 20%. Methyl (R)-2-chloromandelate is key intermediate of clopidogrel and should be enantiopure. Considering the enantioselective nature of enzyme, biological transformation of ketones into optically active alcohols could be an efficient strategy. In the present study, we investigate the factors that influence the reduction of methyl-2-chlorobenzoylformate to find optimum conditions enabling the efficient production of methyl (R)-2-chloromandelate. [This work was supported by the Small & Medium Business Administration] |
| 저자 | 정 민, 홍순호, 유익근 |
| 소속 | 울산대 |
| 키워드 | enantioselective conversion; platelet aggregation inhibitor; Saccharomyces cerevisiae; whole cell biocatalyst |
| 원문파일 | 초록 보기 |
