| 학회 | 한국공업화학회 |
| 학술대회 | 2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 | 24권 1호 |
| 발표분야 | 포스터-정밀화학 |
| 제목 | One-pot Synthesis of 4-quinolones via Iron-catalyzed Oxidative Coupling of Alcohol and Methyl Arene |
| 초록 | 4-Quinolones are a privileged N-heterocyclcic moiety and possess various biological activities. Moreover, it has been used as important building blocks for various quinolone and quinoline compounds, because of facile fuctionalization of their reactive center on 1,3 and 4 position. The attractive biological profile and synthetic importance encourage researchers to develop various synthetic method for this scaffold. However, most of cases required the specific substrates or aldehydes as a starting materials. Alcohols and hydrocarbons are easily available and usually supplied as a feedstock. Therefore, direct use of these substrates instead of labile aldehyde is more attractive in generality of reaction scope. Herein, we described the iron-catalyzed oxidative annulation of alcohol and methyl arene with 2-amino phenyl ketone to synthesize 4-quinolones. This method provides direct approach to synthesize 4-quinolones from less-functionalized substrates. |
| 저자 | 이석범, 홍석창 |
| 소속 | 서울대 |
| 키워드 | cross-dehydrogenative coupling; alcohol; methyl arene; quinolone; oxidation |
