| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
약물 및 유전자 전달용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Fabrication of microcapsules for sustained release of doxorubicin by O/W method |
| 초록 |
In this study, we formulated PLGA/dextran double-layered microspheres by varying the molecular weight and concentration of PLGA and examined their feasibility as drug carriers for sustained drug release. Doxorubicin loaded dextran/PLGA microspheres were prepared by an oil/water emulsion method. The in vitro doxorubicin release from the double-layered microspheres was studied in phosphate buffered saline incubating the microspheres at 37℃ under constant shaking. The release profiles show that all double layered microspheres had a minimal initial burst. The drug release studies in vitro suggest that the release of hydrophilic drugs from the double layered microspheres is highly dependent on the molecular weight and concentration of PLGA. The results from this study indicate that dextran/PLGA double-layered microspheres by a simple method present great potential as drug carriers for sustained and controlled drug delivery. This research was supported by WCU(R31-20029). |
| 저자 |
엄신1, 박종학2, 안식일2, 김용기2, 이동원2, 이종문2, 강길선2
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| 소속 |
1전북대, 2전북대 나노공학부 |
| 키워드 |
double-layered microspheres |
| E-Mail |
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