| 초록 |
Cyclodextrin nanoparticles, mineralized by calcium phosphate, were synthesized as a sustained delivery system for proteins. Carboxy methyl dextran was modified with β-cyclodextrins by chemically attaching ethylenediamine derivative of β-cyclodextrin to carboxy-methyl dextran backbone. Dex-βCD nanoparticles were readily mineralized in the presence of calcium nitrate and ammonium phosphate, which was confirmed by various instruments such as FT-IR, thermogravimetric analysis, field emission transmission electron microscopy, X-ray diffraction spectroscopy and energy dispersive X-ray photoelectron spectroscopy. Minerlaization reduced the particle size of the Dex-βCD NPs in PBS buffer (pH 7.4) from 330 nm to 142 nm, indicating the formation of compact nanoparticles. When CAB loaded mineralized Dex-βCD NPs were exposed to PBS buffer (pH 7.4), CAB was released in a sustained manner for 21 days, suggesting that mineralization effectively reduced the release rate. |
