| 학회 |
한국고분자학회 |
| 학술대회 |
2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 |
29권 1호, p.340 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Human Bone Marrow Stromal Cell Responses on Electrospun Silk Fibroin Mats |
| 초록 |
Electrospinning for the formation of nanoscale diameter fibers has been explored for high performance filters and biomaterial scaffolds for vascular grafts or wound dressings. Fibers with nanoscale diameters provide benefits due to high surface area. In this study we used electrospinning for protein-based biomaterials to fabricate scaffolds from aqueous regenerated silkworm silk, Bombyx mori, solutions. Adhesion, spreading, proliferation, and collagen matrix production of human bone marrow stem cells (hBMSCs) on electrospun silk was characterized. Scanning electron microscopy (SEM) and MTT analyses demonstrated that the electrospun silk matrices promoted hBMSC attachment and proliferation over 10 days in culture when compared with native silk fiber matrices. The responses of the hBMSCs on the electrospun silk matrices, combined with the biocompatibile properties of the silk fibroin protein matrix, suggest potential for use of this biomaterial as scaffolds for tissue engineering. |
| 저자 |
진형준1, J. Chen2, V. Karageorgiou3, G. H. Altman2, D. L. Kaplan3
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| 소속 |
1인하대, 2Department of Chemical & Biological Engineering, 3Tufts Univ. |
| 키워드 |
Electrospinning; Nano-fiber; Silkworm silk; Scaffolds; human bone marrow stem cells (hBMSCs)
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| E-Mail |
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