| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Glucose-responsive polymeric nanoparticles for cancer therapy |
| 초록 |
Functionalized polymeric nanoparticles has recently found potential for the detection and treatment of various diseases including cancer. Various cancer cells show critical damage of mitochondrial respiration and hypoxia stress, leading to high aerobic glycolysis compared to normal cells. In this study, we hypothesized that glucose-responsive nanoparticles could be useful to induce glucose deprivation of cancer cells and their metabolic control could lead to apoptotic cell death. Phenylboronic acid, reversibly binds to diols in glucose, was chemically conjugated to the backbone of polysaccharide and glucose-responsive nanoparticles were prepared via self-assembly. Various physiochemical properties of glucose-responsive nanoparticles and their anti-glycolysis effect were investigated in vitro. We also evaluated anti-cancer efficacy of glucose-responsive nanoparticles using a tumor-bearing mouse model after intravenous injection. |
| 저자 |
조민영1, 이장욱1, 손새진2, 김광명2, 권익찬2, 이근용1
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| 소속 |
1한양대, 2한국과학기술(연) |
| 키워드 |
glucose-responsive nanoparticles; cancer metabolic control; glucose deprivation; phenylboronic acid; glycol chitosan
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| E-Mail |
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