| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation and Release Behavior of Atorvastatin calcium-loaded Polyoxalate Microspheres |
| 초록 |
Atorvastatin calcium is a potent inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-Co A), the rate limiting enzyme in cholesterol biosynthesis. POX microspheres loaded atorvastatin calcium were prepared by an emulsion solvent-evaporation/extraction method like oil-in-oil-in-water (O/O/W). The influence of several preparation parameters such as initial drug ratio, molecular weight of POX, concentration of POX and concentration of emulsifier has been investigated on the drug release profiles. The results, POX microspheres by preparation parameters were able to observe the characteristic of release profiles. Physicochemical properties and morphology of preparation POX microspheres were investigated by SEM, XRD, DSC and FT-IR. In this study, the microspheres made on simple formulation and the control of drug release profiles. This research was supported by WCU (R31-20029). |
| 저자 |
오승창, 김경희, 김영래, 김혜민, 김슬지, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Atorvastain calcium; Polyoxalate; Microspheres; Solvent evaporation method
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| E-Mail |
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