| 초록 |
Plasmonic nanomaterials have huge potential due to the intrinsic properties, LSPR, and photothermal effect for cancer therapy. Herein, we propose plasmonic photo-nanozymes based on Au/Pd bimetallic nanostructures as POD-nanozymes for the combinational PDT and PTT. Underlying mechanism was attributed to the generated hot carriers and efficient separation via introduction of Pd NPs. The overall electron distribution of Pd NPs were changed due to the collected hot electrons. Thus, the introduction of plasmonic NPs increase the overall POD activity of Pd NPs by LSPR effect. Under 808 nm-NIR light irradiation, in vitro phototherapy effect was investigated and the overall therapeutic effect of our photo-nanozymes were enhanced under the light illumination, suggesting the combinational photothermal and photodynamic effect. In addition, we confirmed that these POD-like plasmonic photo-nanozymes could reduce the expression of VEGF and HIF-1α, just like natural peroxidase. |
