| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-무기재료 |
| 제목 |
Transition Metal decorated Anisotropic Gold Nanoparticle as Photo-enhanced Nanozyme for Cancer Therapy |
| 초록 |
Anisotropic gold nanoparticles possessing localized surface plasmon resonance (LSPR) have shown emerging interest to enhance the catalytic activities. LSPR can offer local electric field enhancement and induce the generation of hot carriers, which subsequently lead to enhanced intrinsic enzyme-like activity for the generation of ROS. Here, we synthesized uniform gold nanostructures, with selective deposition of transition metal at the end. The rational design herein proposed allowed a facile collection of induced hot carriers at the incorporated metal centers, facilitating the generation of hydroxyl radicals. LSPR-enhanced peroxidase-like activity was further confirmed by hydrogen peroxide and TMB. Under NIR light irradiation, in vitro enzymetic therapeutic effect could be significantly enhanced. Our work highlights the ability of this novel and highly efficient hybrid nanocomposite as a NIR-responsive tumor therapy. |
| 저자 |
유수빈1, 장도협2, 김동하1, 김세훈2
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| 소속 |
1이화여자대, 2Korea Institute of Science and Technology |
| 키워드 |
nanozyme; peroxidase-like activity; plasmonics; photodynamic cancer therapy
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| E-Mail |
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