| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Surface Sealable Poly(ε-caprolactone) (PCL) Hollowed Nanoparticles and On-Demand Pore Generability for Easy Loading and NIR Light-Triggered Opening System for Drug Release. |
| 초록 |
An easy loading system using NIR Light-Triggered Opening Property for Drug Release is introduced. It consists of hollowed PCL nanoparticles with surface openings containing a biodegradable fatty acid with phase-change ability and a biocompatible photothermal agent. These openings not only enhance the connectivity between the interior and the exterior but enable the easy loading of drug molecules into the interior voids. When the photothermal agent exposures to a NIR light irradiation, it generates heat that raises the local temperature of the hollow particles above the melting point of the fatty acid, and consequently, the instant release of the encapsulated drug molecules through the pores. The activity of the hyperthermia effect from the photothermal agent and the NIR-triggered release of the drug molecules results in noticeable anticancer efficacy. |
| 저자 |
홍상기1, 현동춘1, 문건대2, 안형주3, 박주향1, 김다인1, 서호준1, 김혜지1
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| 소속 |
1경북대, 2한국생산기술(연), 3포항가속기(연) |
| 키워드 |
porous particle; poly(ε-caprolactone); hollow particle; NIR-triggered drug release; anticancer activity
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| E-Mail |
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