| 초록 |
A novel method for preparing the PLGA (poly(lactide-co-glycolide)) nanospheres with hydrophilic surface has been designed and characterized. Hydrophilized PLGA nanospheres have been prepared based on the solvent/non-solvent method with hydrophilizing the surface of PLGA nanospheres. Because of good solubility of tetraglycol in water, PLGA nanospheres were formed by spraying the PLGA/tetraglycol solution into water. The size of PLGA nanospheres was manipulated by changing the concentration of PLGA/tetraglycol solution. Based on the hydrophobic interaction between PLGA and poly(propylene oxide) domain of F-127 (one of Pluronics, poly(ethylene oxide)-poly(propylenes oxide)-poly(ethylene oxide) triblock copolymer), F-127-coated PLGA nanospheres were prepared to enhance the stability of PLGA nanospheres in the aqueous media. For the application as a drug delivery vehicle, it was characterized by measuring the loading amount, the encapsulation efficiency and the release pattern of drug. Paclitaxel used as a potent anticancer drug was selected as a model drug.
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