| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Growth Factor-Loaded F-68/PVA/Chitosan Composite Nanoparticles for Cartilage Regeneration |
| 초록 |
F-68/PVA/chitosan composite nanoparticles were designed and characterized for the growth factor delivery. TGF-β2, transforming growth factor-β2, was used as a model growth factor. F-68/chitosan composite prepared heparin immobilized F-68 and chitosan molecules via ionic interaction. After that, chitosan modified F-68 solution and PVA solution were mixed with vigorous stirring to form to F-68/PVA/chitosan nanoparticles. For growth factor loading, TGF-β2 dissolved in PBS is mainly adsorbed on the chitosan-modified F-68. To prepare the nanoparticles in the powdery state, F-68/PVA/chitosan composite nanoparticles were freeze-dried. Field emission scanning electron microscopy (FE-SEM), zeta-potential, and particle size analyzer were used to characterize the nanoparticles. The release pattern of loaded growth factor was measured by using ELISA kit, respectively. As a result, with the immobilization of heparin into the F-68/PVA composite, the sustained release of TGF-β2 was accomplished. |
| 저자 |
구형모1, 김병진1, 엄윤식1, 오근상1, 조선행2, 육순홍1
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| 소속 |
1한남대, 2한국화학(연) |
| 키워드 |
nanoparticles; hydrogel; growth factor; sustained release
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| E-Mail |
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