| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
In vivo tracking of Mesenchymal stem cells migration by MRI |
| 초록 |
This study is focused to evaluate the efficiency of labeling mesenchymal stem cells (MSC) with novel iron oxide nano particles to enable in vitro cellular imaging and non-invasive in vivo tracking of stem cells through Magnetic Resonance Imaging (MRI). We prepared iron oxide nanoparticles coated with biocompatible polymer, polyvinylpyrrolidone (PVP). The polyninylpyrrolidone-coated iron oxide nanoparticles were uptaken in the cytoplasms of Kupffer cells of rabbit liver. The intercellular migration of transplanted stem cells towards the ablated site in rabbit was clearly tracked through in vivo MRI and also by prussian blue staining of muscular tissues. The resulting superparamagnetic nanoparticles exhibited the feasibility for MRI contrast agent for liver and we performed in vitro and in vivo test. |
| 저자 |
최혜정1, Alavala Matta Reddy2, 박지선1, 곽병국2, 공광훈2, 육순홍1, 조선행1
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| 소속 |
1한국화학(연), 2중앙대 |
| 키워드 |
MRI; Mesenchymal stem cell; in vivo
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| E-Mail |
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