| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Gold/Chitosan composite Nanoparticles for Drug Delivery System with Diagnostic Functionality |
| 초록 |
Gold/chitosan composite nanoparticles has been designed and characterized as a drug delivery system with diagnostic functionality. Gold/chitosan composite nanoparticle was prepared by absorbing cationic chitosan molecules on the negative gold nanoparticles surface. For drug loading, Tween 80 containing paclitaxel was absorbed on the surface of gold nanoparticles by hydrophobic interaction. To prepare the nanoparticles in the powdery state, iron gold/chitosan composite nanoparticles were freeze-dried in the Pluronic F-68 aqueous solution. Transmittance Electron Microscopy (TEM) and electrophoretic light scattering (ELS), uv-visible spectroscopy were used to characterize the nanoparticles. As a result, Gold nanoparticles used a diagnostic probe increased stability by Chitosan. Composite nanoparticles show the sustained release of loaded drug. Gold/chitosan composite nanoparticles in this study can be utilized as a drug delivery system for anti-cancer drug with diagnostic functionality. |
| 저자 |
오근상1, 김은지1, 엄윤식1, 조선행2, 육순홍1
|
| 소속 |
1한남대, 2한국화학(연) |
| 키워드 |
composite nanoparticles; diagnostic functionality; drug delivery; gold nanoparticles
|
| E-Mail |
|
