| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Preparation and Characterization of Doxorubicin Loaded Core/Shell Nanoparticles for Anti-Cancer Drug Delivery. |
| 초록 |
Doxorubicin loaded core/shell nanoparticles were prepared and characterized as a drug delivery system. The lipid core is composed of lecithin and polymeric shell is composed of Pluronic (poly(ethylene oxide)-poly(propylene oxide)- poly(ethylene oxide) triblock copolymer, F-68). The freeze-drying of doxorubicin loaded lipid core was performed in the F-68 aqueous solution containing trehalose used as a cryoprotectant to form stabilized core/shell nanoparticles. FE-SEM (field emission-scanning electron microscopy) was used to observe the morphology of core/shell nanoparticles and electrophoretic light scattering was used to observe the particle size and zeta potential. doxorubicin was loaded into the core/shell nanoparticles by electrostatic interaction. As a result of release pattern, the core/shell nanoparticles show the sustained release of loaded drug. The core/shell nanoparticles in this study can be utilized as a drug delivery system for anti-cancer drug. |
| 저자 |
오근상1, 구형모1, 엄윤식1, 김은지1, 조선행2, 육순홍1
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| 소속 |
1한남대, 2한국화학(연) |
| 키워드 |
core/shell nanoparticles; electrostatic interaction; Poloxamer; Doxorubicin; Sustained release
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| E-Mail |
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