| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생체재료 |
| 제목 |
Label-free tomographic imaging is applicable to therapeutic evaluation of targeted nanodrugs in lipid-laden foam cells |
| 초록 |
Lipid droplet accumulation is a key feature of foam cells and an attractive target for therapeutic intervention in atherosclerosis. However, the availability of non-invasive and quantitative methods is highly limited for use in living foam cells. Here, using optical diffraction tomography, we performed quantitative morphological and biophysical analysis of living foam cells in a label-free manner. We also identified lipid droplets in foam cells by verifying the specific refractive index. Furthermore, through time-lapse monitoring, we precisely and quantitatively evaluated the therapeutic effects of a nanodrug designed to affect the targeted delivery to foam cells. |
| 저자 |
안재원1, 박상우2, 김현정3, 김진원3, 이성수2, 박경순1
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| 소속 |
1중앙대, 2한국기초과학지원(연), 3고려대 |
| 키워드 |
Lipid droplet; Optical Diffraction Tomography; Refractive index; Foam cell; Nanodrug
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| E-Mail |
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